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Nitidine chloride
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Catalog No. T5S0761Cas No. 13063-04-2
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and identifies efficacy in vivo in a mouse model of HCC.
Nitidine chloride
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Purity: 99.55%
Catalog No. T5S0761Cas No. 13063-04-2
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and identifies efficacy in vivo in a mouse model of HCC.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $48 | In Stock | In Stock | |
| 10 mg | $81 | In Stock | In Stock | |
| 25 mg | $133 | In Stock | In Stock | |
| 50 mg | $198 | In Stock | In Stock | |
| 100 mg | $293 | - | In Stock | |
| 200 mg | $437 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.55%
Color:Yellow
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Product Introduction
Nitidine chloride AI Summary
Nitidine chloride exhibits a wide range of bioactivities, demonstrating significant anticancer, antimicrobial, and antiviral properties. In mouse models, it shows potential anticancer activity against L1210 and M5076 sarcoma with T/C values of 136.0 and 137.0, respectively, at a dosage of 100 mg/kg, as well as against P388 lymphocytic leukemia with a T/C value of 129.0% at the same dose. Additionally, it exhibits potent activity against various human cancer cell lines, including human KB cells (ED50 of 4.3 µg/mL), HeLa S3 cells (IC50 of 0.05 µg/mL), HT-29 cells (IC50 of 2750.0 nM), HCT116 (IC50 of 4420.0 nM), HepG2 (IC50 of 3520.0 nM), and HL60 (IC50 of 3410.0 nM). It has also shown promising results in NCI's anticancer drug screening program with a GI50 value of 125.0 nM against a human cancer cell line.
In addition to its anticancer effects, Nitidine chloride inhibits the growth of Plasmodium falciparum strains with an IC50 of 400.0 nM and demonstrates antiviral activity against HIV1 RF in human CEM-SS cells with an EC50 of 14000.0 nM. It also shows inhibitory effects on HIV1 RT at an IC50 value of less than 50.0 µg/mL and on AMV reverse transcriptase at concentrations of 40-50 µg/mL resulting in 50% enzyme inhibition. Moreover, it has been effective in inhibiting human DNA ligase 1 with an IC50 of 25.0 µg/mL, and human T-cell proliferation with an IC50 of 400.0 nM.
Nitidine chloride also possesses broad antimicrobial and antifungal activities, with significant growth inhibition of Micrococcus luteus, Staphylococcus aureus, Mycobacterium smegmatis, Mycobacterium avium, Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae, and Aspergillus niger. These findings highlight Nitidine chloride as a molecule with diverse therapeutic potentials, warranting further investigation and development..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and identifies efficacy in vivo in a mouse model of HCC. |
| Molecular Weight | 383.82 |
| Formula | C21H18ClNO4 |
| Cas No. | 13063-04-2 |
| Smiles | [Cl-].COc1cc2c[n+](C)c3c(ccc4cc5OCOc5cc34)c2cc1OC |
| Relative Density. | 1.35g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 3.84 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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